Tissue deformation during electrode insertion can have significant repercussions in preclinical research, inducing inflammation, gliosis and loss of neuronal density and complexity. Chronic tissue compression negatively impacts the localization of cortex-spanning electrodes, requiring post-hoc channel alignment between subjects, reducing the number of active channels and increasing data analysis duration and complexity. Additionally, chronic tissue strain has been shown to negatively impact neuronal excitability, reducing the quality of single and multi-unit recordings. By minimizing tissue deformation, the NeuralGlider Inserter ensures precise electrode positioning, reduced tissue damage and standardized insertions, enabling researchers to obtain reliable and high-quality single and multi-unit recordings immediately following insertion. Using the NeuralGlider Inserter simplifies surgical procedures and data analysis pipelines, facilitating groundbreaking discoveries.

“The pia mater was left intact to minimize hemorrhaging due to its dense vasculature, which could be disrupted during electrode insertion. Thus, ultrasonic micro-vibration [NeuralGlider] was used during insertion for pia mater penetration of a-SiC microelectrode arrays, which was needed due to the thin and flexible characteristics of ultrasmall a-SiC electrode arrays.”

“Recording of pig neuronal activity in the comparative context of the awake human brain.” 

Aksharkumar Dobariya, Tarek Y. El Ahmadieh, Levi B. Good, Ana G. Hernandez-Reynoso, Vikram Jakkamsetti, Ronnie Brown, Misha Dunbar, Kan Ding, Jesus Luna, Raja Reddy Kallem, William C. Putnam, John M. Shelton, Bret M. Evers, Amirhossein Azami, Negar Geramifard, Stuart F. Cogan, Bruce Mickey & Juan M. Pascual